Elevated Fibroblast Growth Factor 23 is a Risk Factor for Kidney Transplant Loss and Mortality
نویسندگان
چکیده
منابع مشابه
Elevated fibroblast growth factor 23 is a risk factor for kidney transplant loss and mortality.
An increased circulating level of fibroblast growth factor 23 (FGF23) is an independent risk factor for mortality, cardiovascular disease, and progression of chronic kidney disease (CKD), but its role in transplant allograft and patient survival is unknown. We tested the hypothesis that increased FGF23 is an independent risk factor for all-cause mortality and allograft loss in a prospective coh...
متن کاملNew insights to fibroblast growth factor 23 in kidney transplant.
Some abnormalities in mineral metabolism are evident even at very early stages of chronic kidney disease (CKD) and are important determinants of subsequent bone and cardiovascular disease.1,2 A decade ago, fibroblast growth factor 23 (FGF23) was recognized by a few as the protein responsible for several rare inherited and acquired syndromes of osteomalacia and rickets.3,4 Only recently have stu...
متن کاملElevated Fibroblast Growth Factor 23 Concentration: Prediction of Mortality among Chronic Kidney Disease Patients.
BACKGROUND The osteocyte-derived hormone, fibroblast growth factor 23 (FGF23), regulates the phosphorus metabolism and suppresses 1,25-dihydroxyvitamin D production, thereby mitigating hyperphosphatemia in patients with renal disorders. An elevated FGF23 level is suggested to be an early biomarker of altered phosphorus metabolism in the initial stages of chronic kidney disease (CKD) and acts as...
متن کاملIs Fibroblast Growth Factor 23 the New Biomarker for Cardiovascular Mortality in Chronic Kidney Disease Patients?
phosphate co-transporters in the kidney’s proximal tubules [5] . It also directly suppresses renal 1α-hydroxylase, decreasing the rate at which 25-hydroxyvitamin D is converted to its active metabolite, 1,25(OH) 2 D 3 [5] . The serum concentration of FGF23 is also highly correlated with a patient’s cystatin C eGFR [4] . Lastly, FGF23 may cause left ventricular hypertrophy by inducing cardiac my...
متن کاملFibroblast growth factor 23 is upregulated in the kidney in a chronic kidney disease rat model
The hormone fibroblast growth factor 23 (FGF23) is secreted from bone and is involved in phosphorus (P) metabolism. FGF23 mainly binds the FGF receptor, which interacts with αKlotho in the kidney or parathyroid and regulates Na-dependent phosphate co-transporter type IIa (NaPi-IIa) and type IIc (NaPi-IIc) expression, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) activity, and parathyroid hormone (PTH)...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2011
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2010080894